Urodynamic properties and neurotransmitter dependence of urinary bladder contractility in the BK channel deletion model of overactive bladder.

@article{Thorneloe2005UrodynamicPA,
  title={Urodynamic properties and neurotransmitter dependence of urinary bladder contractility in the BK channel deletion model of overactive bladder.},
  author={Kevin S. Thorneloe and Andrea L Meredith and Anna M. Knorn and Richard W. Aldrich and Mark T. Nelson},
  journal={American journal of physiology. Renal physiology},
  year={2005},
  volume={289 3},
  pages={F604-10}
}
Overactive bladder and incontinence are major medical issues, which lack effective therapy. Previously, we showed (Meredith AL, Thornloe KS, Werner ME, Nelson MT, and Aldrich RW. J Biol Chem 279: 36746-36752, 2004) that the gene mSlo1 encodes large-conductance Ca2+-activated K+ (BK) channels of urinary bladder smooth muscle (UBSM) and that ablation of mSlo1 leads to enhanced myogenic and nerve-mediated contractility and increased urination frequency. Here, we examine the in vivo urodynamic… CONTINUE READING

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