Urocortin increases IL-4 and IL-10 secretion and reverses LPS-induced TNF-alpha release from human trophoblast primary cells.

@article{Torricelli2009UrocortinII,
  title={Urocortin increases IL-4 and IL-10 secretion and reverses LPS-induced TNF-alpha release from human trophoblast primary cells.},
  author={Michela Torricelli and Chiara Voltolini and Enrrico Bloise and Giulia Biliotti and Alessia Giovannelli and Maria De Bonis and A. Imperatore and Felice Petraglia},
  journal={American journal of reproductive immunology},
  year={2009},
  volume={62 4},
  pages={224-31}
}
PROBLEM As urocortin (Ucn) is a placental peptide belonging to the corticotrophin-releasing hormone (CRH) family that modulates immune function in other biological models, this study evaluated Ucn effects on cytokines secretion from cultured human trophoblast cells. METHOD OF STUDY Placentas were collected from normal term pregnancies after elective caesarean section, and primary trophoblast culture was prepared followed by the treatment of Ucn and/or CRH selective antagonists, antalarmin and… CONTINUE READING

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