Urocortin affects migration of hepatic cancer cell lines via differential regulation of cPLA2 and iPLA2.

@article{Zhu2014UrocortinAM,
  title={Urocortin affects migration of hepatic cancer cell lines via differential regulation of cPLA2 and iPLA2.},
  author={Chao Zhu and Zongxing Sun and Chuanhua Li and Rui Guo and Li Li and Lai Jin and Rong Wan and Shengnan Li},
  journal={Cellular signalling},
  year={2014},
  volume={26 5},
  pages={1125-34}
}
Urocortin (UCN) is a member of corticotrophin-releasing factor (CRF) family, which has been reported to play a role in many biological processes, including inflammation and cancer development. Growing evidence shows that PLA2 (phospholipase A2) enzymes also participate in inflammation and tumor development. The primary aim of the present study was to identify a novel signaling pathway of CRF receptor activation leading to migration of two kinds of hepatoma carcinoma cell lines, HepG2 and SMMC… CONTINUE READING
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