Urocortin 2 modulates glucose utilization and insulin sensitivity in skeletal muscle.

@article{Chen2006Urocortin2M,
  title={Urocortin 2 modulates glucose utilization and insulin sensitivity in skeletal muscle.},
  author={Alon M Chen and Bhawanjit K. Brar and Cheol Soo Choi and David Rousso and Joan Vaughan and Yael Kuperman and Shee Ne Kim and Cindy Donaldson and Sean M. Smith and Pauline M. Jamieson and Chien – Yi Li and Tim R Nagy and Gerald I Shulman and K Lee and Wylie Vale},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 44},
  pages={16580-5}
}
Skeletal muscle is the principal tissue responsible for insulin-stimulated glucose disposal and is a major site of peripheral insulin resistance. Urocortin 2 (Ucn 2), a member of the corticotropin-releasing factor (CRF) family, and its cognate type 2 CRF receptor (CRFR2) are highly expressed in skeletal muscle. To determine the physiological role of Ucn 2… CONTINUE READING