Urocortin 2 lowers blood pressure and reduces plasma catecholamine levels in mice with hyperadrenergic activity.

@article{Gu2010Urocortin2L,
  title={Urocortin 2 lowers blood pressure and reduces plasma catecholamine levels in mice with hyperadrenergic activity.},
  author={Yusu Gu and Kuixing Zhang and N. B. Ghosh Biswas and Ryan Friese and Dennis Han-Chung Lin and Sushil K Mahata and Masahiko Hoshijima and Daniel T. O'Connor and Kirk L. Peterson and Bhawanjit K. Brar},
  journal={Endocrinology},
  year={2010},
  volume={151 10},
  pages={4820-9}
}
Exaggerated adrenergic activity is associated with human hypertension. The peptide urocortin 2 (Ucn 2) inhibits catecholamine synthesis and secretion from adrenal chromaffin cells in vitro and administration to mammals lowers blood pressure (BP). The chromogranin A-null mouse (Chga-/-) manifests systemic hypertension because of excessive catecholamine secretion from the adrenal and decreased catecholamine storage. In the present study, we investigated whether systemic administration of Ucn 2… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 48 references

Similar Papers

Loading similar papers…