Urocortin 2 infusion in human heart failure.

  title={Urocortin 2 infusion in human heart failure.},
  author={Mark E. Davis and Christopher J. Pemberton and Timothy G. Yandle and Steve F. Fisher and John G. Lainchbury and Chris Frampton and Miriam Tessa Rademaker and Mark Richards},
  journal={European heart journal},
  volume={28 21},
AIMS To document the haemodynamic, neurohormonal, and renal responses to Urocortin 2 (UCN2) infused in human heart failure (HF). METHODS AND RESULTS Eight male patients with HF [left ventricular ejection fraction (LVEF) < 40%, NYHA class II-III] received placebo and 25 [low dose (LD)] and 100 microg [high dose (HD)] of UCN2 intravenously over 1 h in a single-blind, placebo-controlled, dose-escalation design. UCN2 increased cardiac output (CO) (mean peak increments +/- SEM; placebo 0.3 +/- 0.1… CONTINUE READING


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