Urocortin 1 microinjection into the mouse lateral septum regulates the acquisition and expression of alcohol consumption.

@article{Ryabinin2008Urocortin1M,
  title={Urocortin 1 microinjection into the mouse lateral septum regulates the acquisition and expression of alcohol consumption.},
  author={Andrey E. Ryabinin and Naomi Yoneyama and Michelle A Tanchuck and Gregory P. Mark and Deborah Ann Finn},
  journal={Neuroscience},
  year={2008},
  volume={151 3},
  pages={780-90}
}
Previous studies using genetic and lesion approaches have shown that the neuropeptide urocortin 1 (Ucn1) is involved in regulating alcohol consumption. Ucn1 is a corticotropin releasing factor (CRF) -like peptide that binds CRF1 and CRF2 receptors. Perioculomotor urocortin-containing neurons (pIIIu), also known as the non-preganglionic Edinger-Westphal nucleus, are the major source of Ucn1 in the brain and are known to innervate the lateral septum. Thus, the present study tested whether Ucn1… CONTINUE READING

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