Urocortin 1 administered into the hypothalamic supraoptic nucleus affects open-field behaviour in rats

@article{Fatima2009Urocortin1A,
  title={Urocortin 1 administered into the hypothalamic supraoptic nucleus affects open-field behaviour in rats},
  author={Ambrin Fatima and Mohammad Fahad Haroon and Gerald Wolf and Mario Engelmann and Mariarosa G. Spina},
  journal={Amino Acids},
  year={2009},
  volume={38},
  pages={1407-1414}
}
The presence of both Urocortin 1 (Ucn1) and corticotropin-releasing factor 2 receptors (CRF2R) in the hypothalamic supraoptic nucleus (SON) suggests that endogenous Ucn1 released within this brain area acts as a local signal that might be involved in the regulation of not only endocrine but also behavioural stress responses. To test this hypothesis, we monitored the effects induced by the administration of a range of doses of synthetic Ucn1 (0.001–1.0 μg) bilaterally into the SON of rats in the… CONTINUE READING
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