Urocortin, a corticotropin-releasing factor-related mammalian peptide, inhibits edema due to thermal injury in rats.

@article{Turnbull1996UrocortinAC,
  title={Urocortin, a corticotropin-releasing factor-related mammalian peptide, inhibits edema due to thermal injury in rats.},
  author={Andrew V. Turnbull and Wylie W. Vale and Catherine Rivier},
  journal={European journal of pharmacology},
  year={1996},
  volume={303 3},
  pages={213-6}
}
Urocortin is a recently characterized mammalian peptide which appears to be an endogenous ligand for corticotropin-releasing factor (CRF) receptors, in particular CRF receptor type 2. The effect of rat urocortin on protein extravasation and edema, produced by immersion of the paws of anesthetized rats in 58 degrees C water for 5 min, was compared to that of rat/human CRF. Urocortin administered i.v. dose-dependently inhibited the leakage of Evans blue dye into the skin of the footpad and the… CONTINUE READING