Urine is a better biomarker source than blood especially for kidney diseases.

@article{Gao2015UrineIA,
  title={Urine is a better biomarker source than blood especially for kidney diseases.},
  author={Youhe Gao},
  journal={Advances in experimental medicine and biology},
  year={2015},
  volume={845},
  pages={
          3-12
        }
}
Change is the soul of biomarker definition. Changes are more likely to be removed from blood because of homeostasis mechanisms of the body. Therefore, urine is probably a better biomarker source than blood. The road map to the urinary biomarker era is proposed. Researchers are reminded the potential opportunities and risks in their study design. Kidney diseases are emphasized as they produce most significant changes in urine. 

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