Urine-concentrating mechanism in the inner medulla: function of the thin limbs of the loops of Henle.

@article{Dantzler2014UrineconcentratingMI,
  title={Urine-concentrating mechanism in the inner medulla: function of the thin limbs of the loops of Henle.},
  author={William H. Dantzler and A. T. Layton and Harold E. Layton and Thomas L Pannabecker},
  journal={Clinical journal of the American Society of Nephrology : CJASN},
  year={2014},
  volume={9 10},
  pages={1781-9}
}
The ability of mammals to produce urine hyperosmotic to plasma requires the generation of a gradient of increasing osmolality along the medulla from the corticomedullary junction to the papilla tip. Countercurrent multiplication apparently establishes this gradient in the outer medulla, where there is substantial transepithelial reabsorption of NaCl from the water-impermeable thick ascending limbs of the loops of Henle. However, this process does not establish the much steeper osmotic gradient… CONTINUE READING
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