• Corpus ID: 24250010

Urine citrate and renal stone disease.

  title={Urine citrate and renal stone disease.},
  author={H Goldberg and L Grass and R Vogl and A. Rapoport and Dimitrios G. Oreopoulos},
  journal={CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne},
  volume={141 3},
  • H. GoldbergL. Grass D. Oreopoulos
  • Published 1 August 1989
  • Medicine
  • CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne
Calcium stone disease is attributable to supersaturation of the urine with calcium and other salts, the presence of substances that promote crystallization and a deficiency of inhibitors of crystallization. Citrate is a potent inhibitor of calcium oxalate and calcium phosphate stone formation whose excretion is diminished in some patients with stone disease owing to idiopathic causes or secondary factors such as bowel disease and use of thiazides. The pH within the proximal tubule cells is an… 

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