Urine-based polymerase chain reaction is not suitable for diagnosing Lyme borreliosis

  • Rachel Murphy
  • Published 2005 in Nature Clinical Practice Rheumatology


to walk practically, but all could walk after the last joint surgery. Over the course of long-term follow-up the percentage of patients capable of walking decreased: 5 years after the first surgery 92% could walk, at 10 years 79% could walk and at 15 years only 60% could walk. The major causes of this decrease in function were cervical spinal lesions, compression fractures, aggravated pulmonary fibrosis, decreased volition with age, and complications of artificial joints including bone fracture, loosening of implants and deep infection. At the time of the study, 34% of patients had already died. In the remaining patients, the survival rate decreased over 15 years, and rapidly so after 10 years. Causes of death included infection, renal failure and inter stitial pneu monia indicating rheumatic disease. The disease activity of RA remained high throughout follow-up, and several patients required additional surgery to maintain their activities of daily living. The investigators conclude that prevention of osteoporosis is essential for improving the outcome of multiple arthroplasty, and that caution against infection and better RA treatment will improve the vital prognosis for multiple arthroplasty patients. Rachel Murphy

DOI: 10.1038/ncprheum0024

Cite this paper

@article{Murphy2005UrinebasedPC, title={Urine-based polymerase chain reaction is not suitable for diagnosing Lyme borreliosis}, author={Rachel Murphy}, journal={Nature Clinical Practice Rheumatology}, year={2005}, volume={1}, pages={67-67} }