Urine and plasma catecholamine and cortisol concentrations after myocardial revascularization. Modulation by continuous sedation. Multicenter Study of Perioperative Ischemia (McSPI) Research Group, and the Ischemia Research and Education Foundation (IREF).

@article{Plunkett1997UrineAP,
  title={Urine and plasma catecholamine and cortisol concentrations after myocardial revascularization. Modulation by continuous sedation. Multicenter Study of Perioperative Ischemia (McSPI) Research Group, and the Ischemia Research and Education Foundation (IREF).},
  author={John Plunkett and Jerry D. Reeves and Luan Ngo and Wayne H Bellows and Steven L. Shafer and Gary W. Roach and John Howse and Ahvie Herskowitz and Dennis Thomas Mangano},
  journal={Anesthesiology},
  year={1997},
  volume={86 4},
  pages={785-96}
}
BACKGROUND Cardiopulmonary bypass is associated with substantial release of catecholamines and cortisol for 12 or more h. A technique was assessed that may mitigate the responses with continuous 12-h postoperative sedation using propofol. METHODS One hundred twenty-one patients having primary elective cardiopulmonary bypass graft (CABG) surgery were enrolled in a double-blind, randomized trial and anesthetized using a standardized sufentanil-midazolam regimen. When arriving at the intensive… CONTINUE READING

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