Urine Collagen Fragments and CKD Progression-The Cardiovascular Health Study.

  title={Urine Collagen Fragments and CKD Progression-The Cardiovascular Health Study.},
  author={Joachim H. Ix and Mary Lou Biggs and Kenneth Jay Mukamal and Luc Djouss{\'e} and David S Siscovick and Russell P Tracy and Ronit Katz and Joseph A Chris Delaney and Paulo H. M. Chaves and Dena E Rifkin and Jan M Hughes-Austin and Pranav S. Garimella and Mark J Sarnak and Michael G. Shlipak and Jorge R Kizer},
  journal={Journal of the American Society of Nephrology : JASN},
  volume={26 10},
Tubulointerstitial fibrosis is common with ageing and strongly prognostic for ESRD but is poorly captured by eGFR or urine albumin to creatinine ratio (ACR). Higher urine levels of procollagen type III N-terminal propeptide (PIIINP) mark the severity of tubulointerstitial fibrosis in biopsy studies, but the association of urine PIIINP with CKD progression is unknown. Among community-living persons aged ≥65 years, we measured PIIINP in spot urine specimens from the 1996 to 1997 Cardiovascular… CONTINUE READING