Urine Biomarkers of Risk in the Molecular Etiology of Breast Cancer

@inproceedings{Gaikwad2009UrineBO,
  title={Urine Biomarkers of Risk in the Molecular Etiology of Breast Cancer},
  author={Nilesh W. Gaikwad and Li Yang and Sandhya Pruthi and James N. Ingle and Nicole P. Sandhu and Eleanor G. Rogan and Ercole L Cavalieri},
  booktitle={Breast cancer : basic and clinical research},
  year={2009}
}
Endogenous estrogens can be bio-activated to endogenous carcinogens via formation of estrogen quinones. Estrogen-3,4-quinones react with DNA to form mutagenic depurinating estrogen-DNA adducts. The carcinogenicity of endogenous estrogens is related to unbalanced estrogen metabolism leading to excess estrogen quinones and formation of depurinating DNA adducts. The present studies were initiated to confirm that relatively high levels of depurinating estrogen-DNA adducts are present in women at… CONTINUE READING

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