Urinary tumor necrosis factor contributes to sodium retention and renal hypertrophy during diabetes.

@article{DiPetrillo2003UrinaryTN,
  title={Urinary tumor necrosis factor contributes to sodium retention and renal hypertrophy during diabetes.},
  author={Keith DiPetrillo and Bonita A. Coutermarsh and Frank A. Gesek},
  journal={American journal of physiology. Renal physiology},
  year={2003},
  volume={284 1},
  pages={F113-21}
}
Nephropathy is a major contributor to overall morbidity and mortality in diabetic patients. Early renal changes during diabetes include Na retention and renal hypertrophy. Tumor necrosis factor (TNF) is elevated during diabetes and is implicated in the pathogenesis of diabetic nephropathy. We tested the hypothesis that TNF contributes to Na retention and renal hypertrophy during diabetes. Rats with streptozotocin-induced diabetes exhibit increased urinary TNF excretion, Na retention, and renal… CONTINUE READING
58 Extracted Citations
49 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 58 extracted citations

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 49 references

Phosphorylation of the tumor necrosis factor receptor CD120a (p55) recruits Bcl-2 and protects against apoptosis

  • V Cottin, AA Van Linden, DW. Riches
  • J Biol Chem
  • 2001
Highly Influential
8 Excerpts

Similar Papers

Loading similar papers…