Urinary tract stone occurrence in the Women's Health Initiative (WHI) randomized clinical trial of calcium and vitamin D supplements.

@article{Wallace2011UrinaryTS,
  title={Urinary tract stone occurrence in the Women's Health Initiative (WHI) randomized clinical trial of calcium and vitamin D supplements.},
  author={Robert B. Wallace and Jean Wactawski-Wende and Michael O'Sullivan and Joseph C. Larson and Barbara Cochrane and Margery Gass and Kamal H. Masaki},
  journal={The American journal of clinical nutrition},
  year={2011},
  volume={94 1},
  pages={270-7}
}
BACKGROUND The Women's Health Initiative (WHI) randomized clinical trial (RCT) of calcium plus vitamin D (CaD) supplements found a 17% excess in urinary tract stone incidence in the supplemented group. This study evaluated whether this risk is modified by participant characteristics. OBJECTIVE We examined the correlates of urinary tract stone occurrence in the CaD arm of the WHI trial. DESIGN We analyzed an RCT involving 36,282 postmenopausal women aged 50-79 y from 40 WHI centers: 18,176… CONTINUE READING