Corpus ID: 44143780

Urinary steroid profiles in doping testing : in relation to natural variation and drug administration

  title={Urinary steroid profiles in doping testing : in relation to natural variation and drug administration},
  author={Jenny Mullen},
To detect doping with endogenous steroids, such as testosterone, biomarkers in urine are measured. These biomarkers include testosterone and some metabolically related steroids. The measured steroids are combined into ratios and together they make up the steroid profile. This steroid profile is followed over time in the Steroid Module of the Athlete Biological Passport. The software used for the passport, calculates individual reference ranges based on the previous results and gives atypical… Expand
1 Citations
Multivariate Interpretation of the Urinary Steroid Profile and Training-Induced Modifications. The Case Study of a Marathon Runner.
The urine samples collected after activity of moderate or high intensity, in terms of cardiac frequency and/or distance run, proved to modify the basal steroid profile, with particular enhancement of testosterone, epitestosterone, and 5α-androstane-3α,17β-diol. Expand


Subject-based steroid profiling and the determination of novel biomarkers for DHT and DHEA misuse in sports.
By combining comprehensive steroid profiles composed of 24 steroid concentrations with Bayesian inference techniques for longitudinal profiling, a selection was made for the detection of DHT and DHEA misuse and a drastic overall increase in sensitivity was obtained. Expand
Confounding factors and genetic polymorphism in the evaluation of individual steroid profiling
An extensive literature review of the multiple factors that could influence the quantitative levels and ratios of endogenous steroids in urine matrix is performed to show the complex process of quantifying the steroid profile within WADA-accredited laboratories. Expand
Statistical discrimination of steroid profiles in doping control with support vector machines.
A support vector machine (SVM) algorithm was developed to statistically evaluate urinary steroid profiles composed of an extended range of steroid profile metabolites and outperforms the current biomarkers with respect to detection sensitivity and accuracy. Expand
Reference ranges for urinary concentrations and ratios of endogenous steroids, which can be used as markers for steroid misuse, in a Caucasian population of athletes
Monitoring a range of endogenous steroids, which constitute the steroid profile, and evaluating their concentrations and ratios against reference ranges could improve the interpretation of the steroids profile in doping analysis. Expand
The alteration of the urinary steroid profile under the stress
The results of the experiment have shown that psychological stress may cause significant changes in the steroid profile, especially in females, and that major fluctuations of T/Et and A/E ratios under the influence of stressogenic factors and physical activity are unlikely. Expand
Androgens and doping tests: genetic variation and pit-falls.
The population based cut-off level for the testosterone : epitestosterone ratio should be replaced by a Bayesian interpretation of consecutive tests in the same individual to reduce the rate of falsely negative or positive results and the number of expensive follow-up tests. Expand
Population based evaluation of a multi-parametric steroid profiling on administered endogenous steroids in single low dose
It can be concluded that population based reference ranges show limited overall performance in detecting misuse of small doses of natural androgens. Expand
Longitudinal monitoring of endogenous steroids in human serum by UHPLC-MS/MS as a tool to detect testosterone abuse in sports
The longitudinal follow-up proposed in this study represents a first example of ‘blood steroid profile’ in doping control analysis, which can be proposed in the future as a complement to the ‘urinary module’ for improving steroid abuse detection capabilities. Expand
Evaluation of longitudinal steroid profiles from male football players in UEFA competitions between 2008 and 2013.
It clearly showed that the longitudinal and individual follow-up of the T/E biomarker of the players is a good tool for target testing in football and UEFA has decided to implement the steroidal module of the ABP from the start of the next European football season in September 2015. Expand
A pilot study on subject‐based comprehensive steroid profiling: novel biomarkers to detect testosterone misuse in sports
This work has shown that the testosterone/epitestosterone (T/E) ratio is the main marker for the detection of testosterone (T) misuse in athletes and that additional steroid profile parameters indicating T misuse can provide substantiating evidence of doping with endogenous steroids. Expand