Urinary serotonin metabolite excretion during cisplatin chemotherapy.

  title={Urinary serotonin metabolite excretion during cisplatin chemotherapy.},
  author={Oliver H G Wilder-Smith and Alain Borgeat and Philippe Chappuis and Mohammad Fathi and Marco Forni},
  volume={72 7},
BACKGROUND Nausea and vomiting associated with cisplatin chemotherapy is a source of major morbidity that remains difficult to control. Acute phase (0-24 hours after induction of chemotherapy) nausea and vomiting parallels plasma serotonin release, which explains the effectiveness of 5HT3 antagonists; serotonin release in the delayed phase (24-48 hours after induction), during which consistent antiemetic control remains elusive, has not been investigated. The effect of propofol, a recent… CONTINUE READING


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