Urinary proteomics links keratan sulfate degradation and lysosomal enzymes to early type 1 diabetes

  title={Urinary proteomics links keratan sulfate degradation and lysosomal enzymes to early type 1 diabetes},
  author={J. Van and Sergi Clotet-Freixas and A. Hauschild and I. Batruch and I. Jurisica and Y. Elia and F. Mahmud and E. Sochett and E. Diamandis and J. Scholey and A. Konvalinka},
  journal={PLoS ONE},
Diabetes is the leading cause of end-stage renal disease worldwide. Our understanding of the early kidney response to chronic hyperglycemia remains incomplete. To address this, we first investigated the urinary proteomes of otherwise healthy youths with and without type 1 diabetes and subsequently examined the enriched pathways that might be dysregulated in early disease using systems biology approaches. This cross-sectional study included two separate cohorts for the discovery (N = 30) and… Expand


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