Urinary porphyrin excretion in children with mercury amalgam treatment: findings from the Casa Pia Children's Dental Amalgam Trial.

@article{Woods2009UrinaryPE,
  title={Urinary porphyrin excretion in children with mercury amalgam treatment: findings from the Casa Pia Children's Dental Amalgam Trial.},
  author={James S. Woods and Michael E. Martin and Brian G Leroux and Timothy A Derouen and Mario F. Bernardo and H S Lu{\'i}s and Jorge G. Leit{\~a}o and Patience L. Simmonds and Diana Echeverria and Tessa C. Rue},
  journal={Journal of toxicology and environmental health. Part A},
  year={2009},
  volume={72 14},
  pages={891-6}
}
Increases in the urinary concentrations of pentacarboxyl- and coproporphyrins and the appearance of the atypical precoproporphyrin have been defined in relation to mercury (Hg) body burden in animal studies, and this change in the porphyrin excretion pattern has been described as a biomarker of occupational Hg exposure and toxicity in adult human subjects. In the present studies, urinary porphyrins were determined in relation to Hg exposure in children and adolescents, 8-18 yr of age, over the… CONTINUE READING