Urinary physiologic and chemical metabolic effects on the urothelial cytotoxicity and potential DNA adducts of o-phenylphenol in male rats.

@article{Smith1998UrinaryPA,
  title={Urinary physiologic and chemical metabolic effects on the urothelial cytotoxicity and potential DNA adducts of o-phenylphenol in male rats.},
  author={Raymond A. Smith and W R Christenson and Mike Bartels and Lora L. Arnold and Melissa St John and Martin Cano and Emily M. Garland and S G Lake and Brad Wahle and DEBRA A. MCNETT and Samuel M Cohen},
  journal={Toxicology and applied pharmacology},
  year={1998},
  volume={150 2},
  pages={402-13}
}
ortho-Phenylphenol (OPP), a fungicide and antibacterial agent with food residues, is carcinogenic to rat bladder. The present studies provide information on changes in urinary composition and urinary metabolites, urothelial cytotoxicity and regenerative hyperplasia, and DNA adducts in male F344 rats fed OPP. An initial experiment evaluated dietary doses of 0, 1,000, 4,000, and 12,500 ppm OPP fed for 13 weeks. There was no evidence of urinary calculi, microcrystalluria, or calcium phosphate… CONTINUE READING