Urinary miR-16 transactivated by C/EBPβ reduces kidney function after ischemia/reperfusion–induced injury

@inproceedings{Chen2016UrinaryMT,
  title={Urinary miR-16 transactivated by C/EBPβ reduces kidney function after ischemia/reperfusion–induced injury},
  author={Hsi-Hsien Chen and Yi-Fan Lan and Hsiao-Fen Li and C. Cheng and Pei-Fang Lai and Wei-hua Li and Heng Lin},
  booktitle={Scientific reports},
  year={2016}
}
Ischemia-reperfusion (I/R) induced acute kidney injury (AKI) is regulated by transcriptional factors and microRNAs (miRs). However, modulation of miRs by transcriptional factors has not been characterized in AKI. Here, we found that urinary miR-16 was 100-fold higher in AKI patients. MiR-16 was detected earlier than creatinine in mouse after I/R. Using TargetScan, the 3'UTR of B-cell lymphoma 2 (BCL-2) was found complementary to miR-16 to decrease the fluorescent reporter activity… CONTINUE READING