Urinary metabolites and health effects in workers exposed chronically to chloronitrobenzene.

  title={Urinary metabolites and health effects in workers exposed chronically to chloronitrobenzene.},
  author={Christopher R Jones and Ovnair Sepai and Yuan Ying Liu and Huifang Yan and Gabriele Sabbioni},
  journal={Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals},
  volume={12 1},
For workers exposed to 4-chloronitrobenzene (4CNB), the major metabolites were determined. Urine were analysed before and after acid hydrolysis to qualify the free and conjugated metabolites of 4CNB. Three conjugated metabolites were identified in exposed workers: the mercapturic acid N-acetyl-S-(4-nitrophenyl)-L-cysteine (NANPC) was the only metabolite detected in non-hydrolysed urine, and accounted for approximately 51% of the total metabolites detected. The two remaining metabolites 4… CONTINUE READING


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