Urinary metabolic fingerprinting for amiodarone-induced phospholipidosis in rats using FT-ICR MS.

@article{Hasegawa2007UrinaryMF,
  title={Urinary metabolic fingerprinting for amiodarone-induced phospholipidosis in rats using FT-ICR MS.},
  author={Mina Hasegawa and S. Takenaka and M. Kuwamura and J. Yamate and S. Tsuyama},
  journal={Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie},
  year={2007},
  volume={59 2},
  pages={
          115-20
        }
}
  • Mina Hasegawa, S. Takenaka, +2 authors S. Tsuyama
  • Published 2007
  • Chemistry, Medicine
  • Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie
  • In the research and development for new therapeutic compounds, there has been a focus on detecting the changes of metabolites induced by drug administration and finding surrogate markers to assess its toxicity. We examined the suitability of urinary metabolic fingerprinting using Fourier transform-ion cyclotron resonance mass spectrometry (FT-ICR MS) for toxicological assessment in the amiodarone (AMD)-induced phospholipidosis (PLD) rat model. There were more than 400 different ion peaks… CONTINUE READING
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