Urinary levels of oxidative DNA and RNA damage among workers exposed to polycyclic aromatic hydrocarbons in silicon production: comparison with 1-hydroxypyrene.

@article{Marie2009UrinaryLO,
  title={Urinary levels of oxidative DNA and RNA damage among workers exposed to polycyclic aromatic hydrocarbons in silicon production: comparison with 1-hydroxypyrene.},
  author={Caroline Marie and J L Ravanat and Carine Badouard and Marie Adeline Marques and Franck Balducci and Anne Ma{\^i}tre},
  journal={Environmental and molecular mutagenesis},
  year={2009},
  volume={50 2},
  pages={88-95}
}
Polycyclic aromatic hydrocarbons (PAH) are ubiquitous occupational and environmental pollutants and the urinary excretion of 1-hydroxypyrene (1-OHP) is classically measured for the determination of PAH exposure internal dose. Some of PAH are tumorigenic due to their metabolites ability to generate DNA adducts and oxidative DNA damage through the production of reactive oxygen species during metabolism. 8-hydroxy-7,8-dihydro-2'-deoxyguanosine (8-OHdGuo) is one of the major oxidative DNA lesions… CONTINUE READING
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