Urinary leukotriene E4 after lysine-aspirin inhalation in asthmatic subjects.

  title={Urinary leukotriene E4 after lysine-aspirin inhalation in asthmatic subjects.},
  author={Pandora E Christie and Philip C. Tagari and Anthony W. Ford-Hutchinson and Cheryl M. Black and A. Markendorf and M. Schmitz-Schumann and Tak Hong Lee},
  journal={The American review of respiratory disease},
  volume={146 6},
The FEV1 and urinary leukotriene E4 (LTE4) concentrations were determined in six aspirin-sensitive and six non-aspirin-sensitive asthmatic subjects before and after inhalation challenge with lysine-aspirin or placebo solution. Lysine-aspirin produced a mean fall in FEV1 of 26.7 +/- 4.9% (mean +/- SEM) in subjects with aspirin sensitivity and of 8.5 +/- 6.5% (mean +/- SEM) in non-aspirin-sensitive asthmatic subjects. The mean baseline urinary LTE4 concentration of 83 pg/mg creatinine (geometric… CONTINUE READING


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