Urinary kallikrein: a physiological regulator of epithelial Na+ absorption.

@article{Lewis1986UrinaryKA,
  title={Urinary kallikrein: a physiological regulator of epithelial Na+ absorption.},
  author={Simon Andrew Lewis and William P. Alles},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1986},
  volume={83 14},
  pages={
          5345-8
        }
}
The apical membrane of the mammalian urinary bladder contains two populations of ionic conductances--one Na+ selective and amiloride blockable, the other cation selective and amiloride insensitive (a leak channel). Addition of kallikrein (an enzyme of unknown function normally found in urine) to the mucosal solution of the mammalian urinary bladder epithelium resulted in the loss (over a 2-hr period) of amiloride-sensitive Na+ current and an increase in the leak current that is amiloride… CONTINUE READING

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Characterization of a partially degraded Na+ channel from urinary tract epithelium

  • The Journal of Membrane Biology
  • 1988
VIEW 6 EXCERPTS
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  • American journal of physiology. Renal physiology
  • 2012
VIEW 1 EXCERPT
CITES BACKGROUND

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  • Current topics in membranes
  • 2007
VIEW 2 EXCERPTS
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  • American journal of physiology. Renal physiology
  • 2003
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