Urinary interleukin-18 is an acute kidney injury biomarker in critically ill children.

  title={Urinary interleukin-18 is an acute kidney injury biomarker in critically ill children.},
  author={Kimberly K Washburn and Michael Zappitelli and Ayse Akcan Arikan and Laura Loftis and Rajesh Yalavarthy and Chirag R Parikh and Charles Louis Edelstein and Stuart L. Goldstein},
  journal={Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association},
  volume={23 2},
BACKGROUND Urinary interleukin-18 (uIL-18) is an earlier acute kidney injury (AKI) biomarker than serum creatinine (SCr) in specific populations. In the present study, the relationship between uIL-18 and AKI was determined in a heterogeneous group of critically ill children. METHODS We studied critically ill children to determine whether uIL-18 was an early predictor of AKI. SCr was determined daily for up to 14 days from mechanical ventilation initiation and up to four serial urine specimens… CONTINUE READING


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