Urinary hydroxyphenytoin/creatinine ratios as an index of compliance in adult epileptic patients on phenytoin therapy.

Abstract

The ratio of the concentration of the phenytoin metabolite hydroxyphenyl phenylhydantoin (HPPH) to the creatinine concentration in morning urine samples was used as an index of compliance in adult epileptic patients on phenytoin therapy. For this purpose, the phenytoin dose was estimated from the urinary HPPH/creatinine ratio with the help of a regression… (More)

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