Urinary hepcidin excretion in patients with myelodysplastic syndrome and myelofibrosis.

@article{Winder2008UrinaryHE,
  title={Urinary hepcidin excretion in patients with myelodysplastic syndrome and myelofibrosis.},
  author={Asher Winder and Rafi Lefkowitz and Hussam Ghoti and Merav Leiba and Tomas Ganz and Elizabeta Nemeth and Eliezer A. Rachmilewitz},
  journal={British journal of haematology},
  year={2008},
  volume={142 4},
  pages={
          669-71
        }
}
Many patients with myelodysplastic syndrome (MDS) develop severe anaemia that requires multiple blood transfusions with consequent iron overload. The absorption of iron from the intestine, iron release from hepatic stores and the recycling of iron by macrophages is negatively regulated by hepcidin, the principal iron-regulatory hormone (Nicolas et al, 2002; Ganz & Nemeth, 2006). Hepcidin regulates iron absorption and distribution by binding to ferroportin, the iron exporter of these cells, and… CONTINUE READING
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