Urinary gamma-glutamyl transferase activity in rats with nonsteroidal anti-inflammatory drug-induced nephrotoxicity.


Excretion of urinary gamma-glutamyl transferase (GGT) was studied in rats following p.o. application of high doses (10 mg/kg/day) of indomethacin, diclofenac sodium or piroxicam for 28 days. Measurements of 24 h urinary GGT activity and urinary creatinine were carried out on 29th day. Histological examinations of kidneys were performed on day 29. The mean… (More)


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