Urinary gamma-carboxyglutamic acid and serum osteocalcin as bone markers: studies in osteoporosis and Paget's disease.

Abstract

Osteocalcin is a major bone matrix protein with high affinity for hydroxyapatite. This property is conferred by several residues of the calcium-binding amino acid gamma-carboxyglutamate (Gla), which requires vitamin K for its biosynthesis. Because this protein may play a role in the local control of calcium deposition or removal in mineralized tissue, we… (More)

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Cite this paper

@article{Gundberg1983UrinaryGA, title={Urinary gamma-carboxyglutamic acid and serum osteocalcin as bone markers: studies in osteoporosis and Paget's disease.}, author={Caren Marie Gundberg and J. Lian and Paul M. Gallop and Jacob J. Steinberg}, journal={The Journal of clinical endocrinology and metabolism}, year={1983}, volume={57 6}, pages={1221-5} }