Urinary excretion of the water channel aquaporin 2 correlated with the pharmacological effect of tolvaptan in cirrhotic patients with ascites

@article{Nakanishi2015UrinaryEO,
  title={Urinary excretion of the water channel aquaporin 2 correlated with the pharmacological effect of tolvaptan in cirrhotic patients with ascites},
  author={Hiroyuki Nakanishi and Masayuki Kurosaki and Takanori Hosokawa and Yuka Takahashi and Jun Itakura and Shoko Suzuki and Yutaka Yasui and N Tamaki and Natsuko Nakakuki and Hitomi Takada and Mayu Higuchi and Yasuyuki Komiyama and Tsubasa Yoshida and Kenta Takaura and Tsuguru Hayashi and Konomi Kuwabara and Sei Sasaki and Namiki Izumi},
  journal={Journal of Gastroenterology},
  year={2015},
  volume={51},
  pages={620-627}
}
The water channel aquaporin 2 (AQP2) at the apical membrane of renal collecting duct cells mediates water reabsorption. The expression of AQP2 at the apical membrane is tightly regulated by vasopressin and was quantitated by measurement of the urinary form by a recently developed ELISA. Tolvaptan, an antagonist of vasopressin type 2 receptor, inhibits water reabsorption in cirrhosis. The aim of this study was to determine the correlation between the pharmacological effect of tolvaptan and the… CONTINUE READING
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