Urinary excretion of modified nucleosides as biological marker of RNA turnover in patients with cancer and AIDS.

@article{Nakano1993UrinaryEO,
  title={Urinary excretion of modified nucleosides as biological marker of RNA turnover in patients with cancer and AIDS.},
  author={Kyoko Nakano and T Nakao and Karl H Schram and W M Hammargren and Tara McClure and Melissa Katz and Eric Petersen},
  journal={Clinica chimica acta; international journal of clinical chemistry},
  year={1993},
  volume={218 2},
  pages={169-83}
}
Using boronate gel affinity chromatography and reversed-phase high-performance liquid chromatography (RP-HPLC), a method for the simultaneous determination of 12 urinary modified nucleosides has been developed. The RP-HPLC fractions were identified by gas chromatography/mass spectrometry analysis. The HPLC quantitation of urinary nucleoside levels before and after surgery of cancer patients suggested that urinary 5'-deoxy-5'-methylthioadenosine and N-[(9-beta-D-ribofuranosyl-9H-purine-6-yl… CONTINUE READING
10 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 10 extracted citations

Similar Papers

Loading similar papers…