Urinary excretion of histidine derivatives in megaloblastic anaemia and other conditions and comparison with the folic acid clearance test.


Urinary excretion of urocanic acid and formimino-glutamic acid in abnormal amounts following oral doses of histidine has been observed not only in most cases of megaloblastic anaemia, but in iron-deficiency anaemia, haemolytic anaemia, and neoplastic disease. The urinary excretion of these substances is increased in those disease states in which an… (More)


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