Urinary excretion of carnitine as a marker of proximal tubular damage associated with platin-based antineoplastic drugs.

  title={Urinary excretion of carnitine as a marker of proximal tubular damage associated with platin-based antineoplastic drugs.},
  author={Manuel Haschke and Tanja Vitins and Saskia L{\"u}de and Liliane Todesco and Kateřina Nov{\'a}kov{\'a} and Richard P Herrmann and Stephan Kr{\"a}henb{\"u}hl},
  journal={Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association},
  volume={25 2},
  • M. HaschkeTanja Vitins S. Krähenbühl
  • Published 1 February 2010
  • Medicine, Biology
  • Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
BACKGROUND Patients treated with cisplatin or carboplatin show increased renal excretion of carnitine. It is currently unclear whether this is also the case for oxaliplatin and which are the responsible mechanisms. METHODS We investigated 22 patients treated either with a single dose of cisplatin, carboplatin or oxaliplatin. Carnitine and kidney function parameters were determined in plasma and urine. Inhibition and mRNA expression of OCTN2, the principle carnitine transporter, were assessed… 

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