Urinary excretion of N1-acetylspermidine and other acetylated and free polyamines in the 1,2-dimethylhydrazine model of experimental rat colon cancer.

@article{Halline1989UrinaryEO,
  title={Urinary excretion of N1-acetylspermidine and other acetylated and free polyamines in the 1,2-dimethylhydrazine model of experimental rat colon cancer.},
  author={Allan G. Halline and Pradeep K. Dudeja and Bret A. Lashner and Thomas A. Brasitus},
  journal={Cancer research},
  year={1989},
  volume={49 17},
  pages={4721-3}
}
1,2-Dimethylhydrazine (DMH) is a potent procarcinogen with selectivity for the colon. Recently, it has been demonstrated that levels of N1-acetylspermidine were elevated 2-3-fold in colonic tumors induced by this agent compared to control tissues. To determine whether alterations in the urinary levels of this acetylated polyamine or other polyamines were… CONTINUE READING