Urinary excretion of 6-hydroxychlorzoxazone as an index of CYP2E1 activity.

@article{Dreisbach1995UrinaryEO,
  title={Urinary excretion of 6-hydroxychlorzoxazone as an index of CYP2E1 activity.},
  author={Albert W Dreisbach and N Ferencz and Nancy Eddy Hopkins and Miguel Garc{\'i}a Fuentes and Arvind B. Rege and William J. George and Juan J. L. Lertora},
  journal={Clinical pharmacology and therapeutics},
  year={1995},
  volume={58 5},
  pages={498-505}
}
OBJECTIVE To determine whether the urinary excretion of 6-hydroxychlorzoxazone is an index of CYP2E1 activity in vivo. METHODS Male volunteers (n = 27; age range, 17 to 36 years) who were abstinent from alcohol were studied. Chlorzoxazone, 500 mg, was given orally and plasma was collected at 31/2, 41/2, 51/2, and 61/2 hours after dosing. Urine was… CONTINUE READING