Urinary epidermal growth factor is excreted from the rat isolated perfused kidney in the absence of plasma.

@article{Jrgensen1993UrinaryEG,
  title={Urinary epidermal growth factor is excreted from the rat isolated perfused kidney in the absence of plasma.},
  author={Per Erik J\orgensen and Sean D Hilchey and Ebba Nex\o and Steen Seier Poulsen and C P Quilley},
  journal={The Journal of endocrinology},
  year={1993},
  volume={139 2},
  pages={227-34}
}
Large amounts of epidermal growth factor (EGF) are excreted in urine and the majority of this urinary EGF appears to be of renal origin. EGF is synthesized in the kidneys as a membrane-bound 160 kDa precursor, in the thick ascending limb of Henle and in the early part of the distal convoluted tubule. Very little is known about how EGF is released from cell membranes into urine but proteolytic cleavage of the membrane-bound EGF precursor seems likely. The purpose of this study was to examine… CONTINUE READING