Urinary concentrations and urine ex-vivo effect of mecillinam and sulphamethizole.

@article{Kerrn2004UrinaryCA,
  title={Urinary concentrations and urine ex-vivo effect of mecillinam and sulphamethizole.},
  author={Mette B Kerrn and Niels Frimodt-M{\o}ller and Frank Espersen},
  journal={Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases},
  year={2004},
  volume={10 1},
  pages={
          54-61
        }
}
Healthy adult volunteers received 1 g of sulphamethizole orally (n = 10) and later 400 mg of pivmecillinam (274 mg of mecillinam) (n = 9). All urine was collected in defined periods over 24 h, and the drug concentrations in urine were determined. For sulphamethizole, the maximum urine concentration for seven subjects was reached in 0-3 h, and for the remaining three in 3-6 h. For mecillinam, eight of the nine subjects attained a maximum urine concentration in 0-3 h, after which the… CONTINUE READING

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