Urinary catecholamine metabolites and effects of clonidine in patients with alcohol amnestic disorder.

@article{Martin1983UrinaryCM,
  title={Urinary catecholamine metabolites and effects of clonidine in patients with alcohol amnestic disorder.},
  author={Peter R. Martin and M. Ebert and E. Kent Gordon and Irwin J. Kopin},
  journal={Clinical pharmacology and therapeutics},
  year={1983},
  volume={33 1},
  pages={19-27}
}
Seven normotensive patients with alcohol amnestic disorder were treated with 2 micrograms/kg clonidine (C) three times daily for 1 wk. Four patients received 12 micrograms/kg/day during the subsequent week; three developed hypotensive symptoms at this dose and remained on 6 micrograms/kg/day. During a predrug placebo period and after 60 hr on each dose of C, urinary excretion rates of catecholamine metabolites were determined. C, 6 micrograms/kg/day, reduced the ratio of norepinephrine (NE… CONTINUE READING