Urinary cGMP concentrations in severe primary pulmonary hypertension.

  title={Urinary cGMP concentrations in severe primary pulmonary hypertension.},
  author={Mirela Bogdan and Marc Humbert and Jeanne Francoual and Catherine Claise and Pierre Duroux and G{\'e}rald Simonneau and Albert Lindenbaum},
  volume={53 12},
BACKGROUND Prognostic evaluation of patients with primary pulmonary hypertension (PPH) requires right heart catheterisation. The development of accurate non-invasive methods for monitoring these patients remains an important task. Cyclic guanosine monophosphate (cGMP) is an indicator of the action of natriuretic peptides and nitric oxide on target cells. Plasma and urinary cGMP concentrations are raised in patients with congestive heart failure in whom they correlate closely with haemodynamic… CONTINUE READING


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