Urinary bladder instability induced by selective suppression of the murine small conductance calcium-activated potassium (SK3) channel.

@article{Herrera2003UrinaryBI,
  title={Urinary bladder instability induced by selective suppression of the murine small conductance calcium-activated potassium (SK3) channel.},
  author={Gerald M. Herrera and Mar{\'i}a J Pozo and Peter Zv{\'a}ra and Georgi V Petkov and Chris T. Bond and John P Adelman and Mark T. Nelson},
  journal={The Journal of physiology},
  year={2003},
  volume={551 Pt 3},
  pages={893-903}
}
Small conductance, calcium-activated potassium (SK) channels have an important role in determining the excitability and contractility of urinary bladder smooth muscle. Here, the role of the SK isoform SK3 was examined by altering expression levels of the SK3 gene using a mouse model that conditionally overexpresses SK3 channels (SK3T/T). Prominent SK3 immunostaining was found in both the smooth muscle (detrusor) and urothelium layers of the urinary bladder. SK currents were elevated 2.4-fold in… CONTINUE READING

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Urinary BladderIs location of biological processUrination
Activation of these channels may be a therapeutic approach for management of non - voiding contractions , a condition which characterizes many types of urinary bladder dysfunctions including urinary incontinence .
The ability to examine bladder function in mice in which SK3 channel expression is selectively altered reveals that these channels have a significant role in the control of non - voiding contractions in vivo .
Suppression of SK3 channel expression did not alter filling pressure , threshold pressure or bladder capacity , but micturition pressure was elevated compared to control mice .
Activation of these channels may be a therapeutic approach for management of non - voiding contractions , a condition which characterizes many types of urinary bladder dysfunctions including urinary incontinence .
Activation of these channels may be a therapeutic approach for management of non - voiding contractions , a condition which characterizes many types of urinary bladder dysfunctions including urinary incontinence .
Activation of these channels may be a therapeutic approach for management of non - voiding contractions , a condition which characterizes many types of urinary bladder dysfunctions including urinary incontinence .
Activation of these channels may be a therapeutic approach for management of non - voiding contractions , a condition which characterizes many types of urinary bladder dysfunctions including urinary incontinence .
Activation of these channels may be a therapeutic approach for management of non - voiding contractions , a condition which characterizes many types of urinary bladder dysfunctions including urinary incontinence .
Activation of these channels may be a therapeutic approach for management of non - voiding contractions , a condition which characterizes many types of urinary bladder dysfunctions including urinary incontinence .
Activation of these channels may be a therapeutic approach for management of non - voiding contractions , a condition which characterizes many types of urinary bladder dysfunctions including urinary incontinence .
Activation of these channels may be a therapeutic approach for management of non - voiding contractions , a condition which characterizes many types of urinary bladder dysfunctions including urinary incontinence .
Activation of these channels may be a therapeutic approach for management of non - voiding contractions , a condition which characterizes many types of urinary bladder dysfunctions including urinary incontinence .
Activation of these channels may be a therapeutic approach for management of non - voiding contractions , a condition which characterizes many types of urinary bladder dysfunctions including urinary incontinence .
Activation of these channels may be a therapeutic approach for management of non - voiding contractions , a condition which characterizes many types of urinary bladder dysfunctions including urinary incontinence .
Activation of these channels may be a therapeutic approach for management of non - voiding contractions , a condition which characterizes many types of urinary bladder dysfunctions including urinary incontinence .
Activation of these channels may be a therapeutic approach for management of non - voiding contractions , a condition which characterizes many types of urinary bladder dysfunctions including urinary incontinence .
Selective suppression of SK3 expression by dietary doxycycline ( DOX ) decreased SK current density in isolated myocytes , increased phasic contractions of isolated urinary bladder smooth muscle strips and exposed high affinity effects of the blocker apamin of the SK isoforms ( SK1 - 3 ) , suggesting an additional participation from SK2 channels .
Selective suppression of SK3 expression by dietary doxycycline ( DOX ) decreased SK current density in isolated myocytes , increased phasic contractions of isolated urinary bladder smooth muscle strips and exposed high affinity effects of the blocker apamin of the SK isoforms ( SK1 - 3 ) , suggesting an additional participation from SK2 channels .
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