Urinary bladder hyporeflexia and reduced pain-related behaviour in P2X 3-deficient mice

@article{Cockayne2000UrinaryBH,
  title={Urinary bladder hyporeflexia and reduced pain-related behaviour in P2X 3-deficient mice},
  author={Debra A. Cockayne and Sara G. Hamilton and Quan-Ming Zhu and Philip M. Dunn and Yu Zhong and Sanja D. Novakovi{\'c} and Annika B. Malmberg and Gary R Cain and Amy E. Berson and Laura Kassotakis and Linda R. Hedley and Wilhelm G. Lachnit and Geoffrey Burnstock and Stephen B. McMahon and Anthony P.D.W. Ford},
  journal={Nature},
  year={2000},
  volume={407},
  pages={1011-1015}
}
Extracellular ATP is implicated in numerous sensory processes ranging from the response to pain to the regulation of motility in visceral organs. The ATP receptor P2X3 is selectively expressed on small diameter sensory neurons, supporting this hypothesis. Here we show that mice deficient in P2X3 lose the rapidly desensitizing ATP-induced currents in dorsal root ganglion neurons. P2X3 deficiency also causes a reduction in the sustained ATP-induced currents in nodose ganglion neurons. P2X3-null… Expand
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TLDR
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