Urinary biomarkers predict brain tumor presence and response to therapy.

@article{Smith2008UrinaryBP,
  title={Urinary biomarkers predict brain tumor presence and response to therapy.},
  author={Edward R Smith and David Zurakowski and Ali Saad and Robert Michael Scott and Marsha A Moses},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2008},
  volume={14 8},
  pages={2378-86}
}
PURPOSE A major difficulty in treating brain tumors is the lack of effective methods of identifying novel or recurrent disease. In this study, we have evaluated the efficacy of urinary matrix metalloproteinases (MMP) as diagnostic biomarkers for brain tumors. EXPERIMENTAL DESIGN Urine, cerebrospinal fluid, and tissue specimens were collected from patients with brain tumors. Zymography, ELISA, and immunohistochemistry were used to characterize the presence of MMP-2, MMP-9, MMP-9/neutrophil… CONTINUE READING