Urinary bikunin determination provides insight into proteinase/proteinase inhibitor imbalance in patients with inflammatory diseases.

@article{Mizon2002UrinaryBD,
  title={Urinary bikunin determination provides insight into proteinase/proteinase inhibitor imbalance in patients with inflammatory diseases.},
  author={Charlotte Mizon and Frank Piva and Viviane Queyrel and Malika Balduyck and {\'E}ric Hachulla and Jacques Mizon},
  journal={Clinical chemistry and laboratory medicine},
  year={2002},
  volume={40 6},
  pages={579-86}
}
Bikunin (BK) is a Kunitz-type proteinase inhibitor responsible for most of the antitryptic activity of urine and so is known as the urinary trypsin inhibitor. As its excretion increases in inflammatory conditions, it is often considered to be a positive acute phase protein (APP). However, the gene for BK is downregulated in inflammation. In human plasma the major part of BK is covalently linked through a glycosaminoglycan chain to one or two homologous peptide heavy chains, thus forming high… CONTINUE READING

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