Urinary angiotensinogen as a potential biomarker of severity of chronic kidney diseases.

  title={Urinary angiotensinogen as a potential biomarker of severity of chronic kidney diseases.},
  author={Hiroyuki Kobori and Naro Ohashi and Akemi Katsurada and Kayoko Miyata and Ryousuke Satou and Toshie Saito and Tatsuo Yamamoto},
  journal={Journal of the American Society of Hypertension : JASH},
  volume={2 5},
We previously reported that urinary excretion rates of angiotensinogen (AGT) provide a specific index of the activity of the intrarenal renin-angiotensin system in angiotensin II-dependent hypertensive rats. Meanwhile, we have recently developed direct enzyme-linked immunosorbent assays (ELISAs) to measure plasma and urinary AGT in humans. This study was performed to test a hypothesis that urinary AGT levels are enhanced in chronic kidney disease (CKD) patients and correlated with some clinical… CONTINUE READING


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