Urinary Phthalate Metabolites and Biomarkers of Reproductive Function in Young Men

@article{Jonsson2005UrinaryPM,
  title={Urinary Phthalate Metabolites and Biomarkers of Reproductive Function in Young Men},
  author={B. Jönsson and J. Richthoff and L. Rylander and A. Giwercman and L. Hagmar},
  journal={Epidemiology},
  year={2005},
  volume={16},
  pages={487-493}
}
Background: High exposure to phthalates, which are ubiquitous contaminants, has been shown in animal studies to produce detrimental effects on male reproductive functions. A recent study in humans reported dose–response relations between low phthalate levels in urine and human semen parameters, which raises the question whether humans are more sensitive to phthalate exposure than animals. Methods: Urine, serum, and semen samples were collected from 234 young Swedish men at the time of their… Expand

Paper Mentions

Phthalate Excretion Pattern and Testicular Function: A Study of 881 Healthy Danish Men
TLDR
The data suggest that both testosterone production and pituitary–hypothalamic feedback may be compromised in individuals excreting a high proportion of primary metabolites of long-chained phthalates relative to the proportion of secondary metabolites. Expand
Phthalate exposure and reproductive parameters in young men from the general Swedish population.
TLDR
DEHP metabolite levels seemed negatively associated with sperm motility and maturation, particularly urinary mono-(2-ethyl-5-carboxypentyl) phthalate (MECPP), which was 11 percentage points lower in the highest quartile of MECPP than in the lowest. Expand
Associations between serum phthalates and biomarkers of reproductive function in 589 adult men.
TLDR
Findings are compatible with a weak anti-androgenic action of DEHP metabolites, but less so for DiNP metabolites, and significant inverse associations between serum levels of the metabolites, the proxies and serum testosterone are observed. Expand
Phthalates exposure of Chinese reproductive age couples and its effect on male semen quality, a primary study.
TLDR
Although the dose-response relationships for MMP and MEP versus sperm concentration were not significant, a significant positive correlation between MEP and straight-line velocity of sperm motion was observed, which may imply some effects of phthalate exposure on semen. Expand
Semen phthalate metabolites, semen quality parameters and serum reproductive hormones: A cross-sectional study in China.
TLDR
It is suggested that environmental exposure to phthalates may impair human semen quality and that sub-fertile couples who present to the Reproductive Center of Tongji Hospital in Wuhan, China are likely to have low semen quality. Expand
Altered Semen Quality in Relation to Urinary Concentrations of Phthalate Monoester and Oxidative Metabolites
TLDR
The present study confirms previous results on the relationship of altered semen quality with exposure to MBP at general population levels and includes measurements of di(2-ethylhexyl) phthalate (DEHP) oxidative metabolites. Expand
Phthalate exposure in association with serum hormone levels, sperm DNA damage and spermatozoa apoptosis: A cross-sectional study in China.
TLDR
The findings strengthen the emerging evidence that exposure to DEHP may alter hormone levels, disrupt sperm DNA integrity and induce spermatozoa apoptosis in a Chinese population. Expand
The relationships between urinary phthalate metabolites, reproductive hormones and semen parameters in men attending in vitro fertilization clinic.
TLDR
Exposure to phthalates is associated with altered reproductive hormones and semen parameters in 599 men attending an in vitro fertilization clinic and Sobel's test indicated that FSH mediated significantly up to 60% of the positive relationship between sperm concentration and MEHHP, while FSH and LH mediated respectively 15 and 12%" of the inverse association between sperm concentrations and %MEHP. Expand
A Pilot Study Associating Urinary Concentrations of Phthalate Metabolites and Semen Quality
Phthalates are ubiquitous industrial chemicals that are reported to adversely affect human reproductive outcomes. Divergent effects on semen quality have been reported in a limited number of studies.Expand
Associations between urinary phthalate concentrations and semen quality parameters in a general population.
TLDR
Urinary levels of metabolites of phthalate diesters are associated with lower total sperm counts, larger sperm head sizes, and higher percentages of morphologically abnormal sperm among males recruited from the general population. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 29 REFERENCES
Phthalate Exposure and Human Semen Parameters
TLDR
There were dose-response relations for mono-butylphthalate and monobenzyl phthalate with one or more semen parameters, and suggestive evidence for monomethyl phhalate with sperm morphology, and the lack of a relation for other phthalates may indicate a difference in spermatotoxicity amongphthalates. Expand
Levels of seven urinary phthalate metabolites in a human reference population.
TLDR
It is strongly suggested that health-risk assessments for phthalate exposure in humans should include diethyl, dibutyl, and benzyl butyl phthalates. Expand
The relationship between environmental exposures to phthalates and DNA damage in human sperm using the neutral comet assay.
TLDR
This study represents the first human data to demonstrate that urinary MEP, at environmental levels, is associated with increased DNA damage in sperm. Expand
Effects of phthalate esters on the developing reproductive tract of male rats
TLDR
DBP was administered during the critical window of development of the male reproductive system, after which the resulting offspring were examined until adulthood and showed marked effects on the developing male reproductive tract, including malformations of the epididymis and vas deferens, and hypospadias. Expand
Male reproductive health and environmental xenoestrogens.
TLDR
The growing number of reports demonstrating that common environmental contaminants and natural factors possess estrogenic activity presents the working hypothesis that the adverse trends in male reproductive health may be, at least in part, associated with exposure to estrogenic or other hormonally active environmental chemicals during fetal and childhood development. Expand
Internal exposure of the general population to DEHP and other phthalates--determination of secondary and primary phthalate monoester metabolites in urine.
TLDR
The concentrations of the secondary, chain oxidized monoester metabolites of DEHP, mono(2-ethyl-5-hydroxyhexyl)phthalate (5OH-MEHP) and mono-n-octylphthalates (MEP) and 5oxo-ME HP are determined in urine samples from the general population to help to perform health risk assessments for the phthalate exposure of the generalpopulation. Expand
Quantitative detection of eight phthalate metabolites in human urine using HPLC-APCI-MS/MS.
TLDR
A high-throughput, robust, sensitive, accurate, and precise assay for simultaneous measurement of trace levels of eight phthalate metabolites in human urine by HPLC-MS/MS to help elucidate potential associations (if any) between human exposure to phthalates and adverse health effects. Expand
Perinatal exposure to the phthalates DEHP, BBP, and DINP, but not DEP, DMP, or DOTP, alters sexual differentiation of the male rat.
TLDR
It is hypothesized that the phthalate esters that altered testis function in the pubertal male rat would also alter testisfunction in the fetal male and produce malformations of androgen-dependent tissues and, in summary, DEHP, BBP, and DINP all altered sexual differentiation, whereas DOTP, DEP, or DMP were ineffective at this dose. Expand
Fetal testosterone insufficiency and abnormal proliferation of Leydig cells and gonocytes in rats exposed to di(n-butyl) phthalate.
TLDR
Whether DBP causes pathologic changes and alterations in androgen status in the testis during the prenatal period of male reproductive tract differentiation and how this affects gonocytes suggests an underlying Sertoli cell dysfunction is investigated. Expand
A biomarker approach to measuring human dietary exposure to certain phthalate diesters
TLDR
Three groups of eight volunteers were administered stable isotope-labelled phthalate diesters in a single dose and the amount of the corresponding phthalates excreted in the urine was measured to assess exposure tophthalate esters via measuring urinary levels of the monoester metabolites. Expand
...
1
2
3
...